: Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection.
: Straus SE, Tosato G, Armstrong G, Lawley T, Preble OT, Henle W, Davey R, Pearson G, Epstein J, Brus I.
: Ann Intern Med; 1985 Jan; 102(1):7-16.
, virologic, and immunologic evaluations for 31 adults with chronic illness and fatigue suggested that
23 had persisting Epstein-Barr virus infection. Among these 23 patients, cellular immune mechanisms were generally normal, but
4 had mild
deficiencies. However, 20 patients had abnormal
profiles specific for Epstein-Barr virus shown by significantly elevated
of antibodies to the viral capsid
or early antigen, or by a deficiency of late-appearing antibodies. In 11 of 15 patients
tested, circulating immune complexes were found. Circulating interferon was not found in 18 patients tested, but the activity of
2-5 oligoadenylate synthetase, an interferon-induced enzyme, was increased in 5 patients studied. Of 19 patients, 18 had persisting
suppressor T-cell activity typically found in patients recovering from acute infectious mononucleosis. We believe that the Epstein-Barr
virus may be associated with chronic illness in adults.